Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948864 | 0.77 | NPC1 (0.48) | MAPK1NPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL18471210 | 0.73 | MAPK1 (0.44) | MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4142949 | 0.73 | ALDH1A1 (0.47) | MAPK1NPC1ALDH1A1HPGD | |
| SCHEMBL18518427 | 0.73 | CYP1A2 (0.50) | MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6579797 | 0.73 | MAPK1 (0.38) | MAPK1NPC1ALDH1A1HPGDSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL9386542 | 0.72 | NPC1 (0.45) | MAPK1NPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6580324 | 0.70 | MAPK1 (0.42) | MAPK1NPC1ALDH1A1 | |
| SCHEMBL8923623 | 0.69 | HCAR3 (0.40) | MAPK1FAAHALDH1A1 | |
| SCHEMBL16199152 | 0.69 | RAB9A (0.41) | MAPK1NPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9111798 | 0.69 | HCAR3 (0.46) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110278711-B | Tricyclosulfones as rory modulators | 百时美施贵宝公司 | 2023-12-15 | — | — | CN | disclosed |
| US-10435369-B2 | Tricyclic sulfones as ROR gamma modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-10-08 | — | — | US | disclosed |
| CN-110278711-A | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | 百时美施贵宝公司 | 2019-09-24 | — | — | CN | disclosed |
| WO-2018089402-A1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |
| US-20180127368-A1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2018-05-10 | — | — | US | disclosed |
| US-20180127368-A1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10435369-B2 | Tricyclic sulfones as ROR gamma modulators | RORC, RORB, RORA | MAPK1 2113/4885NPC1 1905/4885FAAH 1509/4885 |
| US-20180127368-A1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | RORC, RORB, RORA | MAPK1 2113/4885NPC1 1905/4885FAAH 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.