Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPRA | P18433 | 1/20 | 0.41 |
| ▸ | PTPRB | P23467 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11726621 | 0.84 | PTPN1 (0.38) | PTPN1MAPTPTPN2PTPRAPTPRB | |
| SCHEMBL7616402 | 0.82 | MAPT (0.41) | MAPTTSHRSMN1; SMN2 | |
| SCHEMBL5806500 | 0.79 | ALDH1A1 (0.48) | MAPTTSHRSMN1; SMN2HIF1AALDH1A1 | |
| SCHEMBL9942148 | 0.78 | ALDH1A1 (0.43) | MAPTTSHRSMN1; SMN2HIF1AALDH1A1 | |
| SCHEMBL7614917 | 0.78 | S1PR1 (0.49) | TSHRALDH1A1LMNAPPARGPPARA | |
| SCHEMBL8491129 | 0.78 | OPRM1 (0.39) | MAPTSMN1; SMN2ALDH1A1LMNAKCNH2 | |
| SCHEMBL7435532 | 0.78 | ALDH1A1 (0.59) | PTPN1MAPTTSHRSMN1; SMN2HIF1A | |
| SCHEMBL7975332 | 0.77 | PTPN1 (0.64) | PTPN1SMN1; SMN2HIF1APTPN2PTPRA | |
| SCHEMBL3531184 | 0.77 | MAPT (0.34) | MAPTALDH1A1 | |
| SCHEMBL5428513 | 0.76 | MAPT (0.39) | MAPTSMN1; SMN2ALDH1A1RECQLCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |