Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.54 |
| ▸ | ESR1 | P03372 | 9/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.52 |
| ▸ | AR | P10275 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | STS | P08842 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10523747 | 1.00 | HSD17B10 (0.67) | HSD17B10LMNANR3C1ESR1ESR2 | |
| SCHEMBL11096095 | 0.90 | LMNA (0.66) | HSD17B10LMNANR3C1ESR1ESR2 | |
| SCHEMBL22926861 | 0.88 | LMNA (0.55) | HSD17B10LMNANR3C1ESR1ESR2 | |
| SCHEMBL6462853 | 0.87 | LMNA (0.62) | HSD17B10LMNAESR1ESR2PGR | |
| SCHEMBL18935677 | 0.87 | LMNA (0.54) | HSD17B10LMNANR3C1ESR1ESR2 | |
| SCHEMBL8775747 | 0.87 | ESR1 (0.70) | HSD17B10LMNANR3C1ESR1ESR2 | |
| SCHEMBL23131175 | 0.86 | LMNA (0.53) | HSD17B10LMNANR3C1ESR1PGR | |
| SCHEMBL18935675 | 0.86 | LMNA (0.53) | HSD17B10LMNANR3C1ESR1ESR2 | |
| SCHEMBL22367760 | 0.86 | LMNA (0.53) | HSD17B10LMNANR3C1ESR1ESR2 | |
| SCHEMBL18919472 | 0.86 | LMNA (0.53) | HSD17B10LMNANR3C1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882439-A | Steroid intermediates | THE UNIVERSITY OF SHEFFIELD (GB) | 1989-11-21 | — | — | US | disclosed |
| EP-0216614-A2 | Synthesis of steroids and intermediates therof | THE UNIVERSITY OF SHEFFIELD (GB) | 1987-04-01 | — | — | EP | disclosed |