Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 10/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | PGR | P06401 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10522508 | 0.90 | HSD17B10 (0.67) | LMNAHSD17B10KDM4EESR1ESR2 | |
| SCHEMBL10523747 | 0.90 | HSD17B10 (0.67) | LMNAHSD17B10KDM4EESR1ESR2 | |
| SCHEMBL6462853 | 0.86 | LMNA (0.62) | LMNAHSD17B10KDM4EESR1ESR2 | |
| SCHEMBL11100019 | 0.85 | ESR1 (0.67) | LMNAHSD17B10KDM4EESR1ESR2 | |
| SCHEMBL11100027 | 0.85 | ESR1 (0.67) | LMNAHSD17B10KDM4EESR1ESR2 | |
| SCHEMBL14569767 | 0.85 | ESR1 (0.67) | LMNAHSD17B10KDM4EESR1ESR2 | |
| SCHEMBL13930477 | 0.85 | ESR1 (0.67) | LMNAHSD17B10KDM4EESR1ESR2 | |
| SCHEMBL11740371 | 0.83 | ESR1 (0.47) | LMNAHSD17B10KDM4EESR1ESR2 | |
| SCHEMBL11741232 | 0.82 | HSD11B1 (0.48) | LMNAHSD17B10KDM4EESR1ESR2 | |
| SCHEMBL5189486 | 0.82 | LMNA (0.49) | LMNAHSD17B10KDM4EESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0044105-B1 | NEW 8-ALPHA-OESTRA-1,3,5(10)-TRIENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1984-10-03 | — | — | EP | disclosed |
| US-4407753-A | 8α-Oestra-1,3,5(10)-triene derivatives, processes for their preparation and pharmaceutical compositions | AKZO N.V. (NL) | 1983-10-04 | — | — | US | disclosed |