Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 7/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 3/20 | 0.33 |
| ▸ | MMP2 | P08253 | 3/20 | 0.33 |
| ▸ | MMP3 | P08254 | 3/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | HPN | P05981 | 1/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10522653 | 0.90 | KLK7 (0.41) | KLK7TLR2TLR1MMP1MMP2 | |
| SCHEMBL10521155 | 0.89 | KLK7 (0.46) | KLK7TLR2TLR1REN | |
| SCHEMBL10519369 | 0.82 | KLK7 (0.43) | KLK7TLR2TLR1REN | |
| SCHEMBL10521150 | 0.82 | KLK7 (0.40) | KLK7TLR2TLR1RENGCK | |
| SCHEMBL10519922 | 0.80 | REN (0.39) | RENCTSSCTSK | |
| SCHEMBL7441367 | 0.79 | KLK7 (0.53) | KLK7TLR2TLR1 | |
| SCHEMBL10519365 | 0.76 | KLK7 (0.38) | KLK7TLR2TLR1GCK | |
| SCHEMBL7274295 | 0.73 | KLK7 (0.42) | KLK7TLR2TLR1RENGCK | |
| SCHEMBL7287334 | 0.73 | KLK7 (0.41) | KLK7REN | |
| SCHEMBL29401167 | 0.72 | KLK7 (0.61) | KLK7TLR2TLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4820691-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-04-11 | — | — | US | disclosed |