Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520785 | 0.96 | ESR1 (0.42) | ESR1ESR2NFE2L2TOP1NPSR1 | |
| SCHEMBL10520398 | 0.91 | ACHE (0.46) | ESR1ESR2NFE2L2TOP1NPSR1 | |
| SCHEMBL10794254 | 0.86 | ESR1 (0.43) | ESR1ESR2NFE2L2TOP1NPSR1 | |
| SCHEMBL10522880 | 0.79 | ACHE (0.38) | ESR1ESR2TOP1NPSR1LMNA | |
| SCHEMBL10522576 | 0.77 | ESR1 (0.58) | ESR1ESR2NFE2L2TOP1NPSR1 | |
| SCHEMBL10522878 | 0.77 | ESR1 (0.58) | ESR1ESR2NFE2L2TOP1NPSR1 | |
| SCHEMBL10524057 | 0.75 | ESR1 (0.42) | ESR1ESR2NFE2L2ACHENPC1 | |
| SCHEMBL10523760 | 0.75 | ACHE (0.46) | ESR1ESR2NFE2L2TOP1NPSR1 | |
| SCHEMBL10795313 | 0.70 | ACHE (0.40) | NFE2L2ACHE | |
| SCHEMBL10340775 | 0.70 | ACHE (0.35) | NFE2L2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4806691-A | Process for the preparation of tertiary phosphine oxides | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-21 | — | — | US | disclosed |
| US-4675446-A | OXIDATION OF PHOSPHINE SULFIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-06-23 | — | — | US | disclosed |