Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.69 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.63 |
| ▸ | CNR2 | P34972 | 1/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | PTGES | O14684 | 1/20 | 0.59 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.59 |
| ▸ | ALB | P02768 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10525346 | 0.97 | PTGS2 (0.67) | PTGS2AKR1C3CNR2PTGS1HRH4 | |
| SCHEMBL10526684 | 0.97 | PTGS2 (0.67) | PTGS2AKR1C3CNR2PTGS1HRH4 | |
| SCHEMBL10526172 | 0.89 | PTGS2 (0.62) | PTGS2AKR1C3CNR2PTGS1HRH4 | |
| SCHEMBL10526360 | 0.88 | PTGS2 (0.61) | PTGS2AKR1C3CNR2PTGS1LMNA | |
| SCHEMBL10526127 | 0.86 | PTGS2 (0.60) | PTGS2AKR1C3CNR2PTGS1HRH4 | |
| SCHEMBL10524719 | 0.85 | PTGS2 (0.63) | PTGS2AKR1C3CNR2PTGS1HRH4 | |
| SCHEMBL10524213 | 0.85 | PTGS2 (0.57) | PTGS2AKR1C3CNR2MEN1CYP1A2 | |
| SCHEMBL10526302 | 0.85 | PTGS2 (0.57) | PTGS2AKR1C3CNR2MEN1CYP1A2 | |
| SCHEMBL10527799 | 0.84 | PTGS2 (0.64) | PTGS2AKR1C3CNR2PTGS1LMNA | |
| SCHEMBL2739299 | 0.82 | PTGS2 (1.00) | PTGS2AKR1C3CNR2PTGS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188803-B1 | PIPERAZINE DERIVATIVE | TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-06-07 | — | — | EP | disclosed |
| US-4696929-A | Derivative of piperazine having anti-allergic and anti-inflammatory action | TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) | 1987-09-29 | — | — | US | disclosed |
| EP-0188803-A1 | Piperazine derivative | TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) | 1986-07-30 | — | — | EP | disclosed |