Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.59 |
| ▸ | CNR2 | P34972 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.57 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | PTGES | O14684 | 1/20 | 0.57 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.57 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10526127 | 0.97 | PTGS2 (0.60) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL10527799 | 0.96 | PTGS2 (0.64) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL10524337 | 0.89 | PTGS2 (0.69) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL10525264 | 0.89 | PTGS2 (0.56) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL10815513 | 0.88 | TSHR (0.57) | PTGS2HIF1AKDM4EMEN1LMNA | |
| SCHEMBL10523837 | 0.87 | PTGS2 (0.59) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL10525346 | 0.86 | PTGS2 (0.67) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL10526684 | 0.86 | PTGS2 (0.67) | PTGS2AKR1C3CNR2PTGS1GLO1 | |
| SCHEMBL10524488 | 0.86 | PTGS2 (0.54) | PTGS2AKR1C3CNR2 | |
| SCHEMBL10524719 | 0.81 | PTGS2 (0.63) | PTGS2AKR1C3CNR2PTGS1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188803-B1 | PIPERAZINE DERIVATIVE | TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-06-07 | — | — | EP | disclosed |
| EP-0188803-A1 | Piperazine derivative | TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) | 1986-07-30 | — | — | EP | disclosed |