SCHEMBL10524736

SCHEMBL10524736

O=C1C2=C(OCO2)C(=O)c2cc(Cl)ccc21

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 2/20 0.59
HSP90AA1 P07900 1/20 0.46
PPOX P50336 1/20 0.44
METAP1 P53582 1/20 0.42
MAOB P27338 3/20 0.41
CES1 P23141 2/20 0.40
USP8 P40818 2/20 0.40
USP7 Q93009 2/20 0.40
TGM2 P21980 1/20 0.40
PTPRC P08575 1/20 0.40
USP47 Q96K76 1/20 0.40
ITGA1 P56199 1/20 0.38
PTPN1 P18031 1/20 0.38
CYP19A1 P11511 1/20 0.37
VHL P40337 1/20 0.37
ELOC Q15369 1/20 0.37
ELOB Q15370 1/20 0.37
F7 P08709 1/20 0.37
PARP1 P09874 1/20 0.37
F3 P13726 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10523086 0.88 S100A4 (0.59) S100A4HSP90AA1PPOXMETAP1MAOB
SCHEMBL10523198 0.81 S100A4 (0.38) S100A4MAOBCES1PTPRC
SCHEMBL4229683 0.80 S100A4 (0.80) S100A4HSP90AA1PPOXMETAP1MAOB
SCHEMBL353693 0.80 S100A4 (0.80) S100A4HSP90AA1PPOXMETAP1MAOB
SCHEMBL10522898 0.78 MALT1 (0.44) MAOBUSP8USP7PTPRCUSP47
SCHEMBL10522287 0.78 ESR2 (0.63) MAOBMAOA
SCHEMBL23271900 0.77 S100A4 (0.67) S100A4HSP90AA1PPOXMETAP1MAOB
SCHEMBL9643067 0.76 S100A4 (0.73) S100A4HSP90AA1PPOXMETAP1MAOB
SCHEMBL10522658 0.76 PKM (0.58) S100A4MAOBCES1PTPRCMAOA
SCHEMBL9627793 0.76 S100A4 (0.59) S100A4HSP90AA1PPOXMETAP1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4840965-A LIPOXYGENASE INHIBITORS SYNTEX (U.S.A.) INC. (US) 1989-06-20 US disclosed