Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31632660 | 1.00 | IRAK4 (0.55) | IRAK4HPGDTSHRKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL28294057 | 0.98 | IRAK4 (0.53) | IRAK4HPGDTSHRKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7849679 | 0.98 | IRAK4 (0.53) | IRAK4HPGDTSHRKDM4EALDH1A1 | |
| Phosphonic Acid SCHEMBL16236589 | 0.92 | IRAK4 (0.49) | IRAK4HPGDTSHRKDM4EALDH1A1 | |
| Formic Acid SCHEMBL15389360 | 0.92 | IRAK4 (0.49) | IRAK4HPGDTSHRKDM4EALDH1A1 | |
| SCHEMBL28292380 | 0.90 | L3MBTL1 (0.49) | IRAK4HPGDTSHRKDM4EALDH1A1 | |
| SCHEMBL9783644 | 0.89 | IRAK4 (0.53) | IRAK4HPGDTSHRKDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3299438 | 0.87 | IRAK4 (0.45) | IRAK4HPGDTSHRKDM4EALDH1A1 | |
| SCHEMBL305563 | 0.87 | IRAK4 (0.52) | IRAK4HPGDTSHRKDM4EALDH1A1 | |
| SCHEMBL731619 | 0.87 | IRAK4 (0.52) | IRAK4HPGDTSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 657 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232020-A1 | TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH INHIBITORS OF MENIN | Kura Oncology, Inc. (US) | 2023-08-30 | — | — | EP | claimed |
| CN-112585140-B | Optically active azabicyclo derivatives | 住友制药株式会社 | 2023-07-04 | — | — | CN | claimed |
| WO-2022155419-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | ESCAPE Bio, Inc. (US) | 2022-07-21 | — | — | WO | claimed |
| US-11369605-B2 | Optically active azabicyclo ring derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2022-06-28 | — | — | US | claimed |
| WO-2022086986-A1 | TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH INHIBITORS OF MENIN | KURA ONCOLOGY, INC. (US) | 2022-04-28 | — | — | WO | claimed |
| CN-112585140-A | Optically active azabicyclo derivatives | 大日本住友制药株式会社 | 2021-03-30 | — | — | CN | claimed |
| US-20200131157-A1 | PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CYSTIC FIBROSIS | ISTITUTO GIANNINA GASLINI (IT) | 2020-04-30 | — | — | US | claimed |
| CN-110511215-A | A kind of aryl piperazines/piperidines and application thereof | UNIV FUDAN | 2019-11-29 | — | — | CN | claimed |
| CN-110283094-A | A kind of synthesis technology of anticancer drug procarbazine | 苏州岚云医药科技有限公司 | 2019-09-27 | — | — | CN | claimed |
| CN-110167556-A | Thio-hydantoin androgen receptor antagonist for treating cancer | 詹森药业有限公司 | 2019-08-23 | — | — | CN | claimed |
| WO-2002100822-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2002-12-19 | — | — | WO | claimed |
| WO-2002066035-A2 | AZOLES AS MALONYL-COA DECARBOXYLASE INHIBITORS USEFUL AS METABOLIC MODULATORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-08-29 | — | — | WO | claimed |
| EP-1150565-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2001-11-07 | — | — | EP | claimed |
| WO-2001074775-A1 | INDOLIN-2-ONE DERIVATIVES, PREPARATION AND THEIR USE AS OCYTOCIN RECEPTOR LIGANDS | SANOFI-SYNTHELABO (FR) | 2001-10-11 | — | — | WO | claimed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | claimed |
| WO-2001034133-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034134-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034199-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2001-05-17 | — | — | WO | claimed |
| WO-2000045635-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2000-08-10 | — | — | WO | claimed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11369605-B2 | Optically active azabicyclo ring derivative | MLLT3, MEN1, MLLT1 | IRAK4 2151/4885HPGD 4619/4885TSHR 3676/4885 |
| US-20200131157-A1 | PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, ABCC5, ABCC3 | IRAK4 1874/4885HPGD 617/4885TSHR 3688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.