Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ELANE | P08246 | 5/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10526290 | 0.86 | TNKS (0.36) | ALDH1A1ELANEGSK3BCCNB2CDK1 | |
| SCHEMBL10525166 | 0.83 | CCNB2 (0.37) | GSK3BCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL10527852 | 0.81 | KDM4E (0.34) | ALDH1A1GSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL10527803 | 0.81 | DHFR (0.35) | GSK3BCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL10527276 | 0.80 | CCNB2 (0.38) | GSK3BCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL10526812 | 0.80 | GSK3B (0.35) | ALDH1A1GSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL10524717 | 0.80 | KAT2B (0.38) | GSK3BCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL10526729 | 0.79 | IDO1 (0.36) | ELANESYKDDB1CRBNCREBBP | |
| SCHEMBL10527375 | 0.79 | KAT2B (0.37) | GSK3BCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL10525447 | 0.78 | BRD4 (0.36) | CCNA2CDK2KDM4EDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4801590-A | ANGINA, ANTICANCER, CARDIOVASCULAR DISORDERS, HEADACHES, PSORIASIS, ASTHMA, ANTICOAGULANTS | BEIERSDORF AG (DE) | 1989-01-31 | — | — | US | disclosed |
| EP-0253171-A1 | Pyrido[1,8]naphthyridinones, process for their preparation and their use and compositions containing them | Beiersdorf-Lilly GmbH (DE) | 1988-01-20 | — | — | EP | disclosed |