Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 5/20 | 0.42 |
| ▸ | CDK1 | P06493 | 5/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10527877 | 0.81 | KAT2B (0.37) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| SCHEMBL10527413 | 0.81 | CCNB2 (0.37) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| SCHEMBL10527139 | 0.81 | CRBN (0.37) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| SCHEMBL10919563 | 0.80 | CRBN (0.38) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| SCHEMBL10526370 | 0.79 | IDO1 (0.39) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| SCHEMBL10526786 | 0.79 | UTS2R (0.41) | PIM1KDM4E | |
| SCHEMBL10526800 | 0.78 | ALDH1A1 (0.37) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| SCHEMBL10525532 | 0.78 | UTS2R (0.39) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| SCHEMBL10527105 | 0.77 | TLR8 (0.46) | PIM1KDM4E | |
| SCHEMBL10525166 | 0.74 | CCNB2 (0.37) | CCNB2CDK1CCNB1CCNB3CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4801590-A | ANGINA, ANTICANCER, CARDIOVASCULAR DISORDERS, HEADACHES, PSORIASIS, ASTHMA, ANTICOAGULANTS | BEIERSDORF AG (DE) | 1989-01-31 | — | — | US | disclosed |
| EP-0253171-A1 | Pyrido[1,8]naphthyridinones, process for their preparation and their use and compositions containing them | Beiersdorf-Lilly GmbH (DE) | 1988-01-20 | — | — | EP | disclosed |