Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.41 |
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29611187 | 0.77 | KDM4E (0.48) | PARP1CA12CA9KDM4ECA1 | |
| SCHEMBL22607244 | 0.77 | KDM4E (0.48) | PARP1CA12CA9KDM4ECA1 | |
| SCHEMBL4464552 | 0.77 | MAPT (0.50) | PARP1LMNACA12CA9AURKA | |
| SCHEMBL8600442 | 0.76 | AXL (0.46) | HCAR2PARP1LMNAKDM4EMAPT | |
| SCHEMBL28115036 | 0.73 | CA12 (0.41) | CA12CA9KDM4EMEN1ALDH1A1 | |
| SCHEMBL730906 | 0.73 | LMNA (0.42) | HCAR2PARP1LMNAAURKAFGFR1 | |
| SCHEMBL30846772 | 0.72 | PARP1 (0.42) | HCAR2PARP1LMNACA12CA9 | |
| SCHEMBL1982985 | 0.71 | CYP3A4 (0.47) | PARP1LMNAAURKAKDM4EMEN1 | |
| SCHEMBL13629310 | 0.69 | ALDH1A1 (0.43) | HCAR2PARP1LMNAAURKAKDM4E | |
| SCHEMBL29871779 | 0.69 | MAPT (0.54) | LMNACA12CA9KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4801590-A | ANGINA, ANTICANCER, CARDIOVASCULAR DISORDERS, HEADACHES, PSORIASIS, ASTHMA, ANTICOAGULANTS | BEIERSDORF AG (DE) | 1989-01-31 | — | — | US | disclosed |
| EP-0253171-A1 | Pyrido[1,8]naphthyridinones, process for their preparation and their use and compositions containing them | Beiersdorf-Lilly GmbH (DE) | 1988-01-20 | — | — | EP | disclosed |