Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25278009 | 0.81 | KDM4E (0.50) | KDM4ESMN1; SMN2PARP1 | |
| SCHEMBL4464552 | 0.80 | MAPT (0.50) | CYP3A4MAPTKDM4ELMNANCOA1 | |
| SCHEMBL1287815 | 0.80 | MCL1 (0.46) | CYP3A4KDM4ESMN1; SMN2MEN1HTT | |
| SCHEMBL2811653 | 0.79 | PKM (0.31) | — | |
| SCHEMBL11117589 | 0.77 | EGFR (0.34) | — | |
| SCHEMBL6089904 | 0.77 | CYP3A4 (0.44) | CYP3A4MAPTKDM4ELMNANCOA1 | |
| SCHEMBL4429036 | 0.77 | MAPT (0.50) | CYP3A4MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL2423608 | 0.77 | LMNA (0.33) | MAPTKDM4ELMNAMEN1HTT | |
| SCHEMBL31567906 | 0.75 | TYMS (0.43) | CYP3A4MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL28491136 | 0.75 | TYMS (0.43) | CYP3A4MAPTKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118420615-A | Method for synthesizing pyridoquinazolinone compound by photo-induced organic catalysis alkyne difunctional cyclization | 南京工业大学 | 2024-08-02 | — | — | CN | claimed |
| CN-117659004-A | Phenothiazine polymerization inhibitor containing pyridoquinazolinone, and preparation method and application thereof | 万华化学集团股份有限公司 | 2024-03-08 | — | — | CN | claimed |
| CN-109438440-B | Triarylamine compound containing pyridoquinazolinone and preparation method and application thereof | 浙江工业大学 | 2020-12-01 | — | — | CN | claimed |
| CN-108997335-B | Pyridino-quinazolinone compound and preparation method and application thereof | 浙江工业大学 | 2020-05-05 | — | — | CN | claimed |
| CN-107698586-B | Method for preparing pyridoquinazolinone compound by catalysis of copper compound | 广州大学 | 2020-02-07 | — | — | CN | claimed |
| EP-0944628-B1 | HETERO-BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | AMERICAN CYANAMID CO (US) | 2002-06-05 | — | — | EP | claimed |
| EP-0944628-A1 | HETERO-BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | American Cyanamid Company (US) | 1999-09-29 | — | — | EP | claimed |
| US-5908840-A | Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents | AMERICAN CYANAMID COMPANY (US) | 1999-06-01 | — | — | US | claimed |
| WO-1998023617-A1 | HETERO-BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | AMERICAN CYANAMID COMPANY (US) | 1998-06-04 | — | — | WO | claimed |
| CN-118420615-A | Method for synthesizing pyridoquinazolinone compound by photo-induced organic catalysis alkyne difunctional cyclization | 南京工业大学 | 2024-08-02 | — | — | CN | disclosed |
| CN-118420615-A | Method for synthesizing pyridoquinazolinone compound by photo-induced organic catalysis alkyne difunctional cyclization | 南京工业大学 | 2024-08-02 | — | — | CN | disclosed |
| CN-118420615-A | Method for synthesizing pyridoquinazolinone compound by photo-induced organic catalysis alkyne difunctional cyclization | 南京工业大学 | 2024-08-02 | — | — | CN | disclosed |
| CN-117659004-A | Phenothiazine polymerization inhibitor containing pyridoquinazolinone, and preparation method and application thereof | 万华化学集团股份有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-117659004-A | Phenothiazine polymerization inhibitor containing pyridoquinazolinone, and preparation method and application thereof | 万华化学集团股份有限公司 | 2024-03-08 | — | — | CN | disclosed |
| EP-0944628-A1 | HETERO-BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | American Cyanamid Company (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5908840-A | Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents | AMERICAN CYANAMID COMPANY (US) | 1999-06-01 | — | — | US | disclosed |
| US-5908840-A | Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents | AMERICAN CYANAMID COMPANY (US) | 1999-06-01 | — | — | US | disclosed |
| WO-1998023617-A1 | HETERO-BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | AMERICAN CYANAMID COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |
| WO-1998023616-A1 | BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | AMERICAN CYANAMID COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |
| WO-1998023617-A1 | HETERO-BIARYL-PYRIDOQUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | AMERICAN CYANAMID COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |