Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080873 | 0.77 | ALDH1A1 (0.73) | CYP19A1ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL11087065 | 0.77 | CYP19A1 (0.67) | CYP19A1ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL10946350 | 0.77 | CYP19A1 (0.67) | CYP19A1ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL11150916 | 0.77 | ALDH1A1 (0.73) | CYP19A1ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL10946345 | 0.77 | CYP19A1 (0.67) | CYP19A1ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL11087066 | 0.77 | CYP19A1 (0.67) | CYP19A1ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL11228351 | 0.74 | ALDH1A1 (0.51) | CYP19A1ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL11228340 | 0.74 | ALDH1A1 (0.51) | CYP19A1ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL11432191 | 0.74 | ALDH1A1 (0.51) | CYP19A1ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL10528860 | 0.74 | CYP19A1 (0.48) | CYP19A1ALDH1A1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0183494-B1 | TRIAZOLE ANTIFUNGAL AGENTS | Pfizer Limited (GB) | 1989-01-11 | — | — | EP | disclosed |
| US-4767777-A | Triazole antifungal agents | PFIZER INC. (US) | 1988-08-30 | — | — | US | disclosed |
| EP-0164246-B1 | TRIAZOLE ANTIFUNGAL AGENTS | Pfizer Limited (GB) | 1988-08-10 | — | — | EP | disclosed |
| US-4618616-A | MAMMALS AND PLANTS; 1,2,4-TRIAZOLE DI-SUBSTITUTED | PFIZER INC. (US) | 1986-10-21 | — | — | US | disclosed |
| EP-0183494-A2 | Triazole antifungal agents | Pfizer Limited (GB) | 1986-06-04 | — | — | EP | disclosed |
| EP-0164246-A2 | Triazole antifungal agents | Pfizer Limited (GB) | 1985-12-11 | — | — | EP | disclosed |