Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 2/20 | 0.40 |
| ▸ | TOP1 | P11387 | 2/20 | 0.40 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10531308 | 0.91 | SLC2A1 (0.44) | GUSBALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL10532657 | 0.90 | GUSB (0.41) | GUSBTOP1TOP2AALDH1A1HPGD | |
| SCHEMBL10646224 | 0.90 | PDE4A (0.49) | GUSBALDH1A1HPGDHSD17B10SCD | |
| SCHEMBL10532282 | 0.88 | AURKB (0.46) | GUSBTOP1TOP2AALDH1A1HPGD | |
| SCHEMBL10650118 | 0.85 | GUSB (0.45) | GUSBTOP1TOP2AALDH1A1HPGD | |
| SCHEMBL10645372 | 0.84 | ALDH1A1 (0.45) | GUSBALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL10534419 | 0.84 | SLC2A1 (0.43) | GUSBALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL10649604 | 0.83 | SLC2A1 (0.44) | GUSBALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL10698967 | 0.83 | AURKB (0.47) | GUSBTOP1TOP2AALDH1A1HPGD | |
| SCHEMBL10530386 | 0.81 | SLC2A1 (0.43) | GUSBALDH1A1HPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831027-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1989-05-16 | — | — | US | disclosed |
| EP-0263352-A1 | Imidazo-benzoxazinones, their preparation and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1988-04-13 | — | — | EP | disclosed |