Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 2/20 | 0.39 |
| ▸ | TOP2A | P11388 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700270 | 0.90 | AURKA (0.47) | AURKBAURKANPBWR1GUSBALDH1A1 | |
| SCHEMBL10698025 | 0.89 | PDE4A (0.51) | AURKBAURKASCDGUSBALDH1A1 | |
| SCHEMBL10699139 | 0.89 | AURKB (0.47) | AURKBAURKANPBWR1SCDGUSB | |
| SCHEMBL10698507 | 0.87 | AURKB (0.59) | AURKBAURKANPBWR1SCDGUSB | |
| SCHEMBL10698233 | 0.85 | AURKA (0.46) | AURKBAURKAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10699944 | 0.85 | AURKA (0.46) | AURKBAURKANPBWR1SCDPDE4A | |
| SCHEMBL10698273 | 0.84 | MAPT (0.47) | AURKBAURKAGUSBALDH1A1HPGD | |
| SCHEMBL10698460 | 0.83 | AURKA (0.48) | AURKBAURKAPDE4APDE4BPDE4C | |
| SCHEMBL10530438 | 0.83 | GUSB (0.40) | AURKBAURKANPBWR1SCDGUSB | |
| SCHEMBL10700220 | 0.82 | SLC2A1 (0.46) | AURKBAURKANPBWR1GUSBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |