Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10530872 | 0.93 | KCNH2 (0.71) | KCNH2MAPTHTR2AOPRM1DRD3 | |
| SCHEMBL30010815 | 0.93 | MAPT (0.61) | KCNH2MAPTHTR2AOPRM1DRD3 | |
| SCHEMBL9630022 | 0.88 | GFER (0.54) | KCNH2MAPTOPRM1DRD3CHRM2 | |
| SCHEMBL10529931 | 0.85 | MAPT (0.64) | KCNH2MAPTHTR2ACHRM2ADRA2A | |
| SCHEMBL22403770 | 0.84 | KCNH2 (0.66) | KCNH2MAPTOPRM1DRD3CHRM2 | |
| SCHEMBL3161700 | 0.84 | GFER (0.54) | KCNH2MAPTOPRM1DRD3CHRM2 | |
| SCHEMBL12128150 | 0.83 | KCNH2 (0.87) | KCNH2OPRM1DRD3DRD2OPRD1 | |
| SCHEMBL640157 | 0.83 | KCNH2 (0.87) | KCNH2OPRM1DRD3DRD2OPRD1 | |
| SCHEMBL12128156 | 0.83 | KCNH2 (0.87) | KCNH2OPRM1DRD3DRD2OPRD1 | |
| SCHEMBL5632446 | 0.82 | KCNH2 (0.56) | KCNH2MAPTHTR2AOPRM1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |