Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10526761 | 0.99 | HSD11B1 (0.42) | HSD11B1ALDH1A1MAPTNPC1RAB9A | |
| Bromide SCHEMBL10526748 | 0.82 | ALDH1A1 (0.54) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| Bromide SCHEMBL10529155 | 0.78 | KMT2A (0.49) | ALDH1A1MAPTRAB9AKMT2AKDM4E | |
| Bromide SCHEMBL10526865 | 0.77 | POLB (0.48) | HSD11B1ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10526750 | 0.75 | POLB (0.46) | HSD11B1ALDH1A1MAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10528498 | 0.74 | POLB (0.45) | HSD11B1ALDH1A1MAPTNPC1RAB9A | |
| Bromide SCHEMBL10529450 | 0.74 | MEN1 (0.47) | HSD11B1ALDH1A1MAPTSMN1; SMN2MEN1 | |
| Bromide SCHEMBL10531147 | 0.72 | ALDH1A1 (0.44) | ALDH1A1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL10528540 | 0.72 | MEN1 (0.48) | HSD11B1ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL2648128 | 0.68 | HSD11B1 (0.54) | HSD11B1ALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182533-B1 | 3-(2-ARYL-2-OXOETHYL)-IMIDAZOLIUM SALTS AS HYPOGLYCEMIC AGENTS | ELI LILLY AND COMPANY (US) | 1989-09-20 | — | — | EP | claimed |