Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10531173 | 0.98 | ALDH1A1 (0.44) | ALDH1A1KMT2AKDM4EGLAPLK1 | |
| Bromide SCHEMBL10526748 | 0.86 | ALDH1A1 (0.54) | ALDH1A1KMT2AKDM4EHTTMAPT | |
| SCHEMBL4394987 | 0.81 | KMT2A (0.54) | ALDH1A1KMT2AKDM4EGLAHTT | |
| Bromide SCHEMBL10529155 | 0.75 | KMT2A (0.49) | ALDH1A1KMT2AKDM4EMAPTLMNA | |
| Bromide SCHEMBL10529210 | 0.75 | POLB (0.51) | ALDH1A1KMT2AKDM4EGLAPLK1 | |
| SCHEMBL10531137 | 0.74 | KMT2A (0.47) | ALDH1A1KMT2AKDM4EHTTMAPT | |
| Bromide SCHEMBL10528580 | 0.73 | KMT2A (0.43) | ALDH1A1KMT2AKDM4EGLAHTT | |
| SCHEMBL10526841 | 0.73 | POLB (0.49) | ALDH1A1KMT2AKDM4EGLAPLK1 | |
| Bromide SCHEMBL10531095 | 0.72 | HSD11B1 (0.41) | ALDH1A1KMT2AKDM4EHTTMAPT | |
| Bromide SCHEMBL10526754 | 0.72 | MAPT (0.51) | ALDH1A1KDM4EGLAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182533-B1 | 3-(2-ARYL-2-OXOETHYL)-IMIDAZOLIUM SALTS AS HYPOGLYCEMIC AGENTS | ELI LILLY AND COMPANY (US) | 1989-09-20 | — | — | EP | claimed |