Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Perazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.68 |
| ▸ | OPRM1 known ✓ | P35372 | 3/20 | 0.68 |
| ▸ | KDM1A | O60341 | 11/20 | 0.84 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | GMNN | O75496 | 2/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 5/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.68 |
| ▸ | DRD2 | P14416 | 5/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.68 |
| ▸ | DRD1 | P21728 | 5/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Perazine SCHEMBL29390464 | 0.92 | KDM1A (1.00) | KDM1AMAPTMAPK1LMNASMN1; SMN2 | |
| Perazine SCHEMBL147165 | 0.92 | KDM1A (1.00) | KDM1AMAPTMAPK1LMNASMN1; SMN2 | |
| Perazine SCHEMBL220703 | 0.91 | MAPT (0.82) | KDM1AMAPTMAPK1LMNASMN1; SMN2 | |
| Perazine SCHEMBL220704 | 0.91 | MAPT (0.82) | KDM1AMAPTMAPK1LMNASMN1; SMN2 | |
| Perazine SCHEMBL2237726 | 0.90 | KDM1A (0.97) | KDM1AMAPTMAPK1LMNASMN1; SMN2 | |
| Perazine SCHEMBL6644457 | 0.90 | KDM1A (0.97) | KDM1AMAPTMAPK1LMNASMN1; SMN2 | |
| SCHEMBL6859184 | 0.89 | KDM1A (0.94) | KDM1AMAPTMAPK1LMNASMN1; SMN2 | |
| Trifluoperazine SCHEMBL27892292 | 0.87 | RAD52 (0.89) | MAPTMAPK1LMNASMN1; SMN2NPSR1 | |
| Perazine SCHEMBL7654455 | 0.86 | CYP3A4 (0.82) | KDM1AMAPTMAPK1LMNASMN1; SMN2 | |
| SCHEMBL26837052 | 0.85 | HRH1 (0.69) | KDM1AMAPTMAPK1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831181-A | OXALIC ACID TREATMENT | STAMICARBON B.V. (NL) | 1989-05-16 | — | — | US | disclosed |