Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trifluoperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.88 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.88 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.88 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.88 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.76 |
| ▸ | RAD52 | P43351 | 3/20 | 0.89 |
| ▸ | FPR2 | P25090 | 12/20 | 0.88 |
| ▸ | LMNA | P02545 | 6/20 | 0.88 |
| ▸ | MAPT | P10636 | 6/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.88 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.88 |
| ▸ | TP53 | P04637 | 3/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.88 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.88 |
| ▸ | HTR1A | P08908 | 2/20 | 0.88 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.88 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoperazine SCHEMBL24866 | 0.94 | FPR2 (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL1897003 | 0.94 | FPR2 (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL29603012 | 0.94 | FPR2 (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL1590788 | 0.93 | RAD52 (0.84) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL1590789 | 0.93 | RAD52 (0.84) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL23039392 | 0.93 | LMNA (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL29579627 | 0.93 | LMNA (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL341516 | 0.93 | LMNA (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL29430171 | 0.93 | LMNA (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 | |
| Trifluoperazine SCHEMBL41194 | 0.93 | LMNA (1.00) | RAD52FPR2LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102690245-A | Method for preparing trifluoperazine hydrochloride | TAICANG HENGYI MEDICAL CHEMICAL RAW MATERIALS PLANT | 2012-09-26 | — | — | CN | claimed |
| CN-102690245-A | Method for preparing trifluoperazine hydrochloride | TAICANG HENGYI MEDICAL CHEMICAL RAW MATERIALS PLANT | 2012-09-26 | — | — | CN | disclosed |