Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Perazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.82 |
| ▸ | MAPT | P10636 | 5/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.82 |
| ▸ | TP53 | P04637 | 4/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.82 |
| ▸ | RAD52 | P43351 | 3/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.82 |
| ▸ | USP2 | O75604 | 2/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.82 |
| ▸ | KDM1A | O60341 | 10/20 | 0.78 |
| ▸ | LMNA | P02545 | 5/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.66 |
| ▸ | HTR1A | P08908 | 4/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.65 |
| ▸ | DRD1 | P21728 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prochlorperazine SCHEMBL40855 | 0.91 | MAPT (1.00) | CYP3A4MAPTMAPK1TP53KDM4E | |
| Prochlorperazine SCHEMBL30903938 | 0.91 | MAPT (1.00) | CYP3A4MAPTMAPK1TP53KDM4E | |
| Perazine SCHEMBL147165 | 0.88 | KDM1A (1.00) | CYP3A4MAPTMAPK1TP53KDM4E | |
| Perazine SCHEMBL29390464 | 0.88 | KDM1A (1.00) | CYP3A4MAPTMAPK1TP53KDM4E | |
| Perazine SCHEMBL2237726 | 0.87 | KDM1A (0.97) | CYP3A4MAPTMAPK1TP53KDM4E | |
| Perazine SCHEMBL6644457 | 0.87 | KDM1A (0.97) | CYP3A4MAPTMAPK1TP53KDM4E | |
| Perazine SCHEMBL10531680 | 0.86 | KDM1A (0.84) | CYP3A4MAPTMAPK1TP53KDM4E | |
| SCHEMBL6859184 | 0.86 | KDM1A (0.94) | CYP3A4MAPTMAPK1TP53KDM4E | |
| Prochlorperazine SCHEMBL10891828 | 0.84 | MAPT (0.90) | CYP3A4MAPTMAPK1TP53KDM4E | |
| Prochlorperazine SCHEMBL1527298 | 0.83 | MAPT (0.89) | CYP3A4MAPTMAPK1TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6491903-B1 | NARROW MOLECULAR WEIGHT DISTRIBUTION SHELL-CORE POLYMERS HAVING HYDROPHILIC, CROSSLINKED PERMEABLE SHELLS AND HYDROPHOBIC CORES, USED FOR REDUCING BLOOD CHOLESTEROL AND BILE ACID UPTAKE IN INTERSTINES; DRUG DELIVERY | WASHINGTON UNIVERSITY | 2002-12-10 | — | — | US | disclosed |
| US-6383500-B1 | Particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain, useful for pharmaceutical and other applications | WASHINGTON UNIVERSITY | 2002-05-07 | — | — | US | disclosed |
| EP-0910351-A1 | PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS | G.D. Searle & Co. (US) | 1999-04-28 | — | — | EP | disclosed |
| EP-0907666-A1 | PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS | G.D. Searle & Co. (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997049736-A2 | PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS | G.D. SEARLE AND CO. (US) | 1997-12-31 | — | — | WO | disclosed |
| WO-1997049387-A1 | PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS | G.D. SEARLE AND CO. (US) | 1997-12-31 | — | — | WO | disclosed |
| US-5082668-A | Osmotic drug delivery | ALZA CORPORATION (US) | 1992-01-21 | — | — | US | disclosed |