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Flumethasone

Flumethasone

SCHEMBL10532810

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nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Flumethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 7/20 0.62
▸ CYP3A4 P08684 8/20 0.72
▸ PGR P06401 7/20 0.72
▸ HIF1A Q16665 6/20 0.72
▸ AR P10275 6/20 0.72
▸ ABCB11 O95342 3/20 0.72
▸ ALDH1A1 P00352 2/20 0.72
▸ MAPT P10636 1/20 0.72
▸ RAB9A P51151 1/20 0.72
▸ SMN1; SMN2 Q16637 1/20 0.72
▸ HSD17B10 Q99714 3/20 0.62
▸ ABCC4 O15439 1/20 0.62
▸ NR1I2 O75469 1/20 0.62
▸ PDE4D Q08499 1/20 0.62
▸ GAA P10253 1/20 0.56
▸ CHRM1 P11229 1/20 0.56
▸ TBXA2R P21731 1/20 0.56
▸ ADRA1A P35348 1/20 0.56
▸ TSHR P16473 2/20 0.55
▸ NFKB1 P19838 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flumethasone SCHEMBL2860002 0.93 PGR (0.81) CYP3A4PGRHIF1AARABCB11
Flumethasone SCHEMBL7901450 0.92 CYP3A4 (0.68) CYP3A4PGRHIF1AARABCB11
Paramethasone SCHEMBL10534685 0.88 PGR (0.81) CYP3A4PGRHIF1AARABCB11
Betamethasone SCHEMBL20576476 0.86 CYP3A4 (0.69) CYP3A4PGRHIF1AARABCB11
Dexamethasone SCHEMBL3877338 0.86 CYP3A4 (0.69) CYP3A4PGRHIF1AARABCB11
Paramethasone SCHEMBL7078196 0.85 PGR (0.76) CYP3A4PGRHIF1AARABCB11
Fluprednisolone SCHEMBL11845328 0.85 PGR (0.81) CYP3A4PGRHIF1AARABCB11
Fluprednisolone SCHEMBL145061 0.85 PGR (0.81) CYP3A4PGRHIF1AARABCB11
Flumethasone SCHEMBL2855052 0.85 CYP3A4 (1.00) CYP3A4PGRHIF1AARABCB11
Flumethasone SCHEMBL19327158 0.85 CYP3A4 (1.00) CYP3A4PGRHIF1AARABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1989008119-A1 HIGH MOLECULAR WEIGHT PRODRUG DERIVATIVES OF ANTI-INFLAMMATORY DRUGS SELCH LARSEN CLAUS (DK) 1989-09-08 — — WO disclosed
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