Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flumethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.68 |
| ▸ | PGR | P06401 | 8/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.68 |
| ▸ | AR | P10275 | 7/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.65 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.65 |
| ▸ | TNF | P01375 | 1/20 | 0.65 |
| ▸ | IL6 | P05231 | 1/20 | 0.65 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.65 |
| ▸ | GLUL | P15104 | 1/20 | 0.65 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.65 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flumethasone SCHEMBL10532810 | 0.92 | CYP3A4 (0.72) | CYP3A4PGRHIF1AARABCB11 | |
| Betamethasone SCHEMBL7070539 | 0.92 | NR3C1 (0.73) | CYP3A4PGRHIF1AARABCB11 | |
| Dexamethasone SCHEMBL3309785 | 0.92 | NR3C1 (0.73) | CYP3A4PGRHIF1AARABCB11 | |
| Dexamethasone SCHEMBL20767432 | 0.90 | CYP3A4 (0.66) | CYP3A4PGRHIF1AARABCB11 | |
| Paramethasone SCHEMBL7078196 | 0.88 | PGR (0.76) | CYP3A4PGRHIF1AARABCB11 | |
| Clobetasol SCHEMBL2857967 | 0.88 | NR3C1 (0.67) | CYP3A4PGRHIF1AARABCB11 | |
| Betamethasone SCHEMBL20576476 | 0.87 | CYP3A4 (0.69) | CYP3A4PGRHIF1AARABCB11 | |
| Dexamethasone SCHEMBL3877338 | 0.87 | CYP3A4 (0.69) | CYP3A4PGRHIF1AARABCB11 | |
| Dexamethasone SCHEMBL4743981 | 0.86 | HSD17B10 (0.65) | CYP3A4PGRHIF1AARABCB11 | |
| Triamcinolone SCHEMBL5151654 | 0.86 | HIF1A (0.72) | CYP3A4PGRHIF1AARABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197761-B1 | ANTIINFLAMMATORY, ANTALLERGEN AGENTS | GLAXO WELLCOME INC. | 2001-03-06 | — | — | US | disclosed |
| EP-0876392-B1 | LACTONE DERIVATIVES OF 17.BETA.-CARBOXY, CARBOTHIO AND AMIDE ANDROSTANE DERIVATIVES | GLAXO GROUP LTD (GB) | 2000-07-05 | — | — | EP | disclosed |
| EP-0876392-A1 | LACTONE DERIVATIVES OF 17.BETA.-CARBOXY, CARBOTHIO AND AMIDE ANDROSTANE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997024365-A1 | LACTONE DERIVATIVES OF 17.BETA.-CARBOXY, CARBOTHIO AND AMIDE ANDROSTANE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1997-07-10 | — | — | WO | disclosed |