SCHEMBL10534136

SCHEMBL10534136

CC1(C)OC(=O)N(Cc2ccccc2)c2cc3nc(-c4cccnc4)[nH]c3cc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
HPGD P15428 4/20 0.47
KDM4E B2RXH2 3/20 0.47
RAB9A P51151 2/20 0.47
MAPT P10636 2/20 0.47
NPC1 O15118 1/20 0.47
STAT1 P42224 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
PGR P06401 2/20 0.44
LDHA P00338 1/20 0.42
EPHX2 P34913 1/20 0.42
ELANE P08246 1/20 0.42
CTSG P08311 1/20 0.42
PRTN3 P24158 1/20 0.42
HTT P42858 1/20 0.41
CYP11B1 P15538 1/20 0.41
HSD17B10 Q99714 2/20 0.40
TP53 P04637 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10532292 0.90 PDE4A (0.48) ALDH1A1HPGDKDM4ERAB9AMAPT
SCHEMBL10532195 0.89 MAPT (0.48) ALDH1A1HPGDKDM4ERAB9AMAPT
SCHEMBL10534240 0.87 HPGD (0.47) ALDH1A1HPGDKDM4ERAB9AMAPT
SCHEMBL10532390 0.86 MAPT (0.46) ALDH1A1HPGDKDM4ERAB9AMAPT
SCHEMBL10646396 0.86 HPGD (0.45) ALDH1A1HPGDKDM4ERAB9AMAPT
SCHEMBL10645372 0.86 ALDH1A1 (0.45) ALDH1A1HPGDKDM4ERAB9AMAPT
SCHEMBL10532541 0.84 MAPT (0.51) ALDH1A1HPGDKDM4ERAB9AMAPT
SCHEMBL10531240 0.84 SLC2A1 (0.44) ALDH1A1HPGDKDM4ERAB9AMAPT
SCHEMBL10696409 0.83 HPGD (0.50) ALDH1A1HPGDKDM4ERAB9AMAPT
SCHEMBL10531372 0.81 MAPT (0.48) ALDH1A1HPGDKDM4ERAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4831027-A USEFUL IN TREATMENT OF CARDIOVASCULAR DISORDERS DR. KARL THOMAE GMBH (DE) 1989-05-16 US disclosed
EP-0263352-A1 Imidazo-benzoxazinones, their preparation and medicaments containing these compounds Dr. Karl Thomae GmbH (DE) 1988-04-13 EP disclosed