Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694210 | 0.89 | PDE4A (0.51) | HPGDALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL10700213 | 0.88 | AURKA (0.56) | HPGDALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL10695470 | 0.87 | MAPT (0.49) | HPGDALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL10697571 | 0.86 | MAPT (0.48) | HPGDALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL10696474 | 0.85 | MAPT (0.47) | HPGDALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL10695484 | 0.84 | MAPT (0.47) | HPGDALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL10698273 | 0.84 | MAPT (0.47) | HPGDALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL10691668 | 0.83 | MAPT (0.54) | HPGDALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL10696080 | 0.83 | TDP1 (0.50) | HPGDALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL10696040 | 0.83 | AURKA (0.49) | KDM4ERAB9AMAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |