Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10972549 | 0.84 | PSEN1 (0.40) | PSEN1LMNAPPARGPTPN1 | |
| SCHEMBL2140130 | 0.82 | PSEN1 (0.53) | PSEN1TSHRALOX5 | |
| SCHEMBL2140140 | 0.82 | PSEN1 (0.53) | PSEN1TSHRALOX5 | |
| SCHEMBL4592776 | 0.81 | PSEN1 (0.65) | PSEN1TSHRALOX5 | |
| SCHEMBL6597291 | 0.81 | PSEN1 (0.65) | PSEN1TSHRALOX5 | |
| SCHEMBL11446060 | 0.80 | PSEN1 (0.44) | PSEN1PPARGALOX5PTPN1 | |
| SCHEMBL11705056 | 0.80 | PSEN1 (0.44) | PSEN1PPARGALOX5PTPN1 | |
| SCHEMBL11701054 | 0.80 | PSEN1 (0.56) | PSEN1TSHRALOX5 | |
| SCHEMBL11625779 | 0.80 | PSEN1 (0.41) | PSEN1PPARGALOX5PTPN1 | |
| SCHEMBL10699108 | 0.80 | PSEN1 (0.41) | PSEN1ALOX5PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0235510-B1 | 3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2H-1-BENZOPYRAN DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1989-03-08 | — | — | EP | claimed |
| US-4806661-A | Chromanemelonate esters | HOFFMANN-LA ROCHE INC. (US) | 1989-02-21 | — | — | US | claimed |
| US-4824971-A | 2-allylchromans | HOFFMAN-LA ROCHE INC. (US) | 1989-04-25 | — | — | US | disclosed |
| US-4806661-A | Chromanemelonate esters | HOFFMANN-LA ROCHE INC. (US) | 1989-02-21 | — | — | US | disclosed |
| US-4752646-A | 2-halochromans | HOFFMANN-LA ROCHE INC. (US) | 1988-06-21 | — | — | US | disclosed |