Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 10/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TTPA | P49638 | 4/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2140130 | 1.00 | PSEN1 (0.53) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL11701054 | 0.91 | PSEN1 (0.56) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL6597291 | 0.90 | PSEN1 (0.65) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL4592776 | 0.90 | PSEN1 (0.65) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL23618084 | 0.83 | PSEN1 (0.46) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL11705056 | 0.83 | PSEN1 (0.44) | PSEN1ALOX5 | |
| SCHEMBL11446060 | 0.83 | PSEN1 (0.44) | PSEN1ALOX5 | |
| SCHEMBL10535018 | 0.82 | PSEN1 (0.44) | PSEN1TSHRALOX5 | |
| SCHEMBL7999828 | 0.82 | PSEN1 (0.46) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL15854990 | 0.82 | PSEN1 (0.54) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240400529-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-12-05 | — | — | US | disclosed |
| US-20240368098-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-11-07 | — | — | US | disclosed |
| US-20240293339-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA | Stealth Bio Therapeutics Inc. (US) | 2024-09-05 | — | — | US | disclosed |
| US-12049455-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | STEALTH BIOTHERAPEUTICS INC. (US) | 2024-07-30 | — | — | US | disclosed |
| EP-4351547-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA | Stealth BioTherapeutics Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| US-20230303506-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. (US) | 2023-09-28 | — | — | US | disclosed |
| US-20230303506-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. (US) | 2023-09-28 | — | — | US | disclosed |
| US-11584728-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | STEALTH BIOTHERAPEUTICS INC. (US) | 2023-02-21 | — | — | US | disclosed |
| US-11584728-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | STEALTH BIOTHERAPEUTICS INC. (US) | 2023-02-21 | — | — | US | disclosed |
| WO-2022261347-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. (US) | 2022-12-15 | — | — | WO | disclosed |
| US-20210206736-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. | 2021-07-08 | — | — | US | disclosed |
| US-20210206736-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | STEALTH BIOTHERAPEUTICS INC. | 2021-07-08 | — | — | US | disclosed |
| WO-2021067836-A1 | CHINONE-, HYDROCHINOME- AND NAPHTHOCHINONE-ANALOGUES OF VATIQUIONE FOR TREATMENT OF MITOCHONDRIAL DISORDER DISEASES | STEALTH BIOTHERAPEUTICS CORP (MC) | 2021-04-08 | — | — | WO | disclosed |
| WO-2021067836-A1 | CHINONE-, HYDROCHINOME- AND NAPHTHOCHINONE-ANALOGUES OF VATIQUIONE FOR TREATMENT OF MITOCHONDRIAL DISORDER DISEASES | STEALTH BIOTHERAPEUTICS CORP (MC) | 2021-04-08 | — | — | WO | disclosed |
| US-8664264-B2 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2014-03-04 | — | — | US | disclosed |
| US-20120251616-A1 | Tocopherols, Tocotrienols, Other Chroman and Side Chain Derivatives and Uses Thereof | SANDERS BOB G (US) | 2012-10-04 | — | — | US | disclosed |
| US-8148424-B2 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2012-04-03 | — | — | US | disclosed |
| US-20100303899-A1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | SANDERS BOB G | 2010-12-02 | — | — | US | disclosed |
| US-7718814-B2 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2010-05-18 | — | — | US | disclosed |
| US-20080161349-A1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | RESEARCH DEVELOPMENT FOUNDATION (US) | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240293339-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA | AIFM2, FH, FECH | PSEN1 168/4885PTGS1 332/4885PTGS2 455/4885 |
| US-20100303899-A1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | TST, TXNRD3, TXNRD1 | PSEN1 3935/4885PTGS1 373/4885PTGS2 600/4885 |
| US-20230303506-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | PSEN1 285/4885PTGS1 682/4885PTGS2 1030/4885 |
| US-11584728-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | FH, COQ8A, TFAM | PSEN1 285/4885PTGS1 682/4885PTGS2 1030/4885 |
| US-20210206736-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | PSEN1 285/4885PTGS1 682/4885PTGS2 1030/4885 |
| US-20240400529-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | PSEN1 285/4885PTGS1 682/4885PTGS2 1030/4885 |
| US-12049455-B2 | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia | FH, COQ8A, TFAM | PSEN1 285/4885PTGS1 682/4885PTGS2 1030/4885 |
| US-20240368098-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA | FH, COQ8A, TFAM | PSEN1 285/4885PTGS1 682/4885PTGS2 1030/4885 |
| US-20080161349-A1 | TOCOPHEROLS, TOCOTRIENOLS, OTHER CHROMAN AND SIDE CHAIN DERIVATIVES AND USES THEREOF | TST, TXNRD3, TXNRD1 | PSEN1 3869/4885PTGS1 367/4885PTGS2 615/4885 |
| US-20120251616-A1 | Tocopherols, Tocotrienols, Other Chroman and Side Chain Derivatives and Uses Thereof | TST, TXNRD3, TXNRD1 | PSEN1 3935/4885PTGS1 373/4885PTGS2 600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.