Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17574701 | 0.88 | POLB (0.37) | POLBNPSR1L3MBTL1TSHRHPGD | |
| SCHEMBL17574697 | 0.86 | TSHR (0.37) | POLBNPSR1L3MBTL1TSHRHPGD | |
| SCHEMBL21959076 | 0.82 | LIPE (0.33) | POLBNPSR1L3MBTL1LIPE | |
| SCHEMBL21207380 | 0.82 | LMNA (0.47) | POLBNPSR1L3MBTL1TSHRKMT2A | |
| SCHEMBL22941384 | 0.80 | CYP2D6 (0.38) | POLBNPSR1L3MBTL1LIPESMN1; SMN2 | |
| SCHEMBL12139988 | 0.77 | EPHX2 (0.49) | POLBNPSR1L3MBTL1TSHRHPGD | |
| SCHEMBL12847618 | 0.76 | EPHX2 (0.51) | POLBNPSR1L3MBTL1TSHRHPGD | |
| SCHEMBL13058141 | 0.76 | EPHX2 (0.51) | POLBNPSR1L3MBTL1TSHRHPGD | |
| SCHEMBL26724832 | 0.75 | CYP1A2 (0.49) | POLBTSHRKMT2AALDH1A1MAPK1 | |
| SCHEMBL26733039 | 0.75 | KMT2A (0.49) | POLBTSHRKMT2AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | NR0B1, GRK7, NR5A2 | POLB 3674/4885NPSR1 550/4885L3MBTL1 4139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.