Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10474303 | 0.88 | ALDH1A1 (0.41) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL10539386 | 0.84 | KEAP1 (0.48) | ALDH1A1KEAP1NFE2L2POLBAPEX1 | |
| SCHEMBL10625944 | 0.82 | ALDH1A1 (0.39) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL8038013 | 0.81 | ALDH1A1 (0.45) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL10540299 | 0.79 | ABL1 (0.41) | ALDH1A1POLBAPEX1HPGDMAPT | |
| SCHEMBL1408926 | 0.79 | ALDH1A1 (0.43) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL12379044 | 0.78 | ALDH1A1 (0.42) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL23035420 | 0.77 | ALDH1A1 (0.34) | ALDH1A1ALOX15MAPT | |
| SCHEMBL12012678 | 0.77 | POLB (0.35) | ALDH1A1KEAP1NFE2L2POLBAPEX1 | |
| SCHEMBL10541272 | 0.77 | KEAP1 (0.35) | ALDH1A1KEAP1NFE2L2POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4870182-A | 4-Hydroxy-quinoline-3-carboxylic | BAYER AKTIENGESELLSCHAFT (DE) | 1989-09-26 | — | — | US | disclosed |
| US-4804760-A | Process for the preparation of 4-hydroxy-quinoline-3-carboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-14 | — | — | US | disclosed |