Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 4/20 | 0.32 |
| ▸ | CES1 | P23141 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8754934 | 0.84 | ALDH1A1 (0.43) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL9766142 | 0.82 | KEAP1 (0.39) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL8974977 | 0.82 | KEAP1 (0.53) | ALDH1A1KEAP1NFE2L2POLBAPEX1 | |
| SCHEMBL9766052 | 0.81 | ALDH1A1 (0.41) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL10539276 | 0.81 | ALDH1A1 (0.41) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL8048009 | 0.81 | ALDH1A1 (0.41) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL5360639 | 0.81 | ALDH1A1 (0.37) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL24710385 | 0.78 | ALDH1A1 (0.54) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL28525271 | 0.78 | ALDH1A1 (0.54) | ALDH1A1ALOX15KEAP1NFE2L2POLB | |
| SCHEMBL29690316 | 0.77 | ALDH1A1 (0.45) | ALDH1A1ALOX15KEAP1NFE2L2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0583705-A1 | Process for the preparation of 2,3,4-trichloro-5-fluoro-benzoylchloride | BAYER AG (DE) | 1994-02-23 | — | — | EP | claimed |
| JP-6157404-A | — | — | None | — | — | JP | disclosed |
| US-11059788-B2 | Streamlined syntheses of fluoroquinolones | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2021-07-13 | — | — | US | disclosed |
| US-20200123111-A1 | STREAMLINED SYNTHESES OF FLUOROQUINOLONES | VIRGINIA COMMONWEALTH UNIVERSITY | 2020-04-23 | — | — | US | disclosed |
| EP-0757667-B1 | PROCESSES FOR PREPARING AROMATIC, BROMINE-CONTAINING COMPOUNDS, NOVEL BROMINE-CONTAINING COMPOUNDS, AND THEIR USE AS INTERMEDIATE PRODUCTS IN THE SYNTHESIS OF ACTIVE AGENTS | BAYER AG (DE) | 2000-04-19 | — | — | EP | disclosed |
| US-5792892-A | BROMINATION IN THE PRESENCE OF ALUMINUM CHLORIDE AND BROMINE AND CHLORINE | BAYER AKTIENGESELLSCHAFT (DE) | 1998-08-11 | — | — | US | disclosed |
| EP-0653412-B1 | Process for preparing 4,5-difluorobenzaldehydes | BAYER AG (DE) | 1998-01-21 | — | — | EP | disclosed |
| US-5489715-A | Process for preparing 4,5-difluorobenzaldehydes | BAYER AKTIENGESELLSCHAFT (DE) | 1996-02-06 | — | — | US | disclosed |
| EP-0653412-A1 | Process for preparing 4,5-difluorobenzaldehydes | BAYER AG (DE) | 1995-05-17 | — | — | EP | disclosed |
| JP-H06157404-A | PREPARATION OF 2,3,4-TRICHLORO-5-FLUORO-BENZOLY CHLORIDE | BAYER AG | 1994-06-03 | — | — | JP | disclosed |
| EP-0583705-A1 | Process for the preparation of 2,3,4-trichloro-5-fluoro-benzoylchloride | BAYER AG (DE) | 1994-02-23 | — | — | EP | disclosed |
| EP-0583705-A1 | Process for the preparation of 2,3,4-trichloro-5-fluoro-benzoylchloride | BAYER AG (DE) | 1994-02-23 | — | — | EP | disclosed |
| EP-0583705-A1 | Process for the preparation of 2,3,4-trichloro-5-fluoro-benzoylchloride | BAYER AG (DE) | 1994-02-23 | — | — | EP | disclosed |
| EP-0266512-B1 | METHOD FOR THE PRODUCTION OF BENZOIC ACID DERIVATIVES FLUORINATED ON THE NUCLEUS | BAYER AG (DE) | 1991-12-04 | — | — | EP | disclosed |
| US-4990661-A | Process for the preparation of benzoic acid derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1991-02-05 | — | — | US | disclosed |
| US-4851160-A | Process for the preparation of benzoic acid derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1989-07-25 | — | — | US | disclosed |
| EP-0266512-A2 | Method for the production of benzoic acid derivatives fluorinated on the nucleus | BAYER AG (DE) | 1988-05-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123111-A1 | STREAMLINED SYNTHESES OF FLUOROQUINOLONES | NRAS, QARS1, BLM | ALDH1A1 3504/4885ALOX15 4139/4885KEAP1 1093/4885 |
| US-11059788-B2 | Streamlined syntheses of fluoroquinolones | NRAS, QARS1, BLM | ALDH1A1 3504/4885ALOX15 4139/4885KEAP1 1093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.