SCHEMBL10540887

SCHEMBL10540887

CN1C(=O)C(c2ccccc2)N(C)C(=O)C1c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.47
KMT2A Q03164 2/20 0.47
MMP2 P08253 6/20 0.44
LMNA P02545 2/20 0.42
BRD4 O60885 3/20 0.42
MEN1 O00255 1/20 0.42
KDM4E B2RXH2 1/20 0.41
PRCP P42785 1/20 0.40
ADORA3 P0DMS8 1/20 0.40
SRD5A1 P18405 1/20 0.40
ALDH1A1 P00352 1/20 0.40
HPGD P15428 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1461678 0.83 TSHR (0.46) TSHRKMT2AMMP2LMNABRD4
SCHEMBL4996175 0.77 PRCP (0.39) TSHRKMT2AMMP2LMNABRD4
SCHEMBL19923468 0.77 LMNA (0.41) TSHRKMT2AMMP2LMNABRD4
SCHEMBL17794055 0.77 LMNA (0.62) TSHRKMT2AMMP2LMNAMEN1
SCHEMBL11746669 0.76 SMN1; SMN2 (0.46) TSHRKMT2AMMP2LMNABRD4
SCHEMBL6077778 0.76 KMT2A (0.37) TSHRKMT2AMMP2LMNABRD4
SCHEMBL15125072 0.76 CHRNB2 (0.50) TSHRKMT2ALMNAKDM4EALDH1A1
SCHEMBL17641492 0.76 LMNA (0.40) TSHRKMT2AMMP2LMNABRD4
SCHEMBL19923426 0.74 LMNA (0.40) TSHRKMT2AMMP2LMNABRD4
SCHEMBL15846794 0.74 BRD4 (0.42) TSHRKMT2AMMP2LMNABRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4846877-A CYCLIC DIMERS OF PHENYLGLYCINE TEIJIN LIMITED (JP) 1989-07-11 US disclosed
US-4772314-A PHENYLGLYCINES, MONOMERIC TEIJIN LIMITED (JP) 1988-09-20 US disclosed
EP-0194679-A2 Plant growth promoter and method of plant growth promotion TEIJIN LIMITED (JP) 1986-09-17 EP disclosed