Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.55 |
| ▸ | PDE4A | P27815 | 4/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.55 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.48 |
| ▸ | NQO1 | P15559 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2564677 | 0.80 | PDE10A (0.54) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL10547699 | 0.79 | CYSLTR1 (0.76) | PDE10ACYSLTR1CYSLTR2HTR2B | |
| SCHEMBL10547669 | 0.79 | CYSLTR1 (0.52) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL10544867 | 0.78 | CYSLTR1 (0.75) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL8732702 | 0.77 | PDE10A (0.66) | PDE10ACYSLTR1CYSLTR2 | |
| SCHEMBL7835368 | 0.77 | NCF1 (0.59) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL10547475 | 0.76 | CYSLTR1 (0.76) | PDE10ACYSLTR1CYSLTR2 | |
| SCHEMBL8180490 | 0.76 | PDE10A (0.47) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL10546719 | 0.76 | CYSLTR1 (0.72) | CYSLTR1 | |
| SCHEMBL13772899 | 0.75 | PDE10A (0.73) | PDE10ACYSLTR1CYSLTR2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4631287-A | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments | USV PHARMACEUTICAL CORP. (US) | 1986-12-23 | — | — | US | claimed |
| EP-0200101-A2 | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive aliments | USV PHARMACEUTICAL CORPORATION (US) | 1986-11-05 | — | — | EP | claimed |
| US-4839369-A | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | RORER PHARMACEUTICAL CORPORATION (US) | 1989-06-13 | — | — | US | disclosed |
| US-4728668-A | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments | USV PHARMACEUTICAL CORPORATION (US) | 1988-03-01 | — | — | US | disclosed |
| US-4725619-A | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments | USV PHARMACEUTICAL CORPORATION (US) | 1988-02-16 | — | — | US | disclosed |
| US-4631287-A | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments | USV PHARMACEUTICAL CORP. (US) | 1986-12-23 | — | — | US | disclosed |
| EP-0200101-A2 | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive aliments | USV PHARMACEUTICAL CORPORATION (US) | 1986-11-05 | — | — | EP | disclosed |