Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180387 | 0.91 | CYSLTR1 (0.48) | PDE10ACYSLTR1CYSLTR2TP53HTT | |
| SCHEMBL2564677 | 0.89 | PDE10A (0.54) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL8186157 | 0.86 | CYSLTR1 (0.53) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL8179931 | 0.83 | PDE10A (0.64) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL8187205 | 0.76 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2 | |
| SCHEMBL9387167 | 0.76 | CYSLTR1 (0.56) | PDE10ACYSLTR1CYSLTR2 | |
| SCHEMBL8180867 | 0.76 | CYSLTR1 (0.46) | PDE10ACYSLTR1CYSLTR2ALOX5ALOX5AP | |
| SCHEMBL10545895 | 0.76 | PDE10A (0.55) | PDE10APDE4APDE4BPDE3BPDE3A | |
| SCHEMBL9337159 | 0.72 | CYSLTR1 (0.54) | PDE10APDE4APDE4BCYSLTR1CYSLTR2 | |
| SCHEMBL7604022 | 0.72 | ALOX5 (0.57) | PDE10APDE4APDE4BPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643045-B1 | Quinoline derivatives as leukotriene antagonists | NOVARTIS AG (CH) | 2000-03-08 | — | — | EP | disclosed |
| US-5508408-A | LEUKOTRIENE ANTAGONISTS | CIBA-GEIGY CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |
| EP-0643045-A1 | Quinoline derivatives as leukoriene antagonists | CIBA-GEIGY AG (CH) | 1995-03-15 | — | — | EP | disclosed |