Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 10/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29306874 | 0.81 | ERN1 (0.42) | ERN1LMNAMAPK1RAB9ACYP3A4 | |
| SCHEMBL4195614 | 0.73 | LMNA (0.46) | ERN1LMNAMAPK1RAB9ACYP3A4 | |
| SCHEMBL8665411 | 0.73 | TSHR (0.59) | LMNAMAPK1RAB9AGPR119NPSR1 | |
| SCHEMBL26091050 | 0.72 | ERN1 (0.44) | ERN1LMNAMAPK1RAB9ACYP3A4 | |
| SCHEMBL9383271 | 0.72 | ERN1 (0.49) | ERN1LMNAMAPK1RAB9ACYP3A4 | |
| SCHEMBL5667693 | 0.72 | ERN1 (0.42) | ERN1LMNAMAPK1RAB9ACYP3A4 | |
| SCHEMBL9191402 | 0.72 | LMNA (0.42) | ERN1LMNAMAPK1RAB9ACYP3A4 | |
| SCHEMBL8924794 | 0.72 | LMNA (0.42) | ERN1LMNAMAPK1RAB9ACYP3A4 | |
| SCHEMBL3992214 | 0.72 | LMNA (0.45) | ERN1LMNAMAPK1RAB9ACYP3A4 | |
| SCHEMBL3997516 | 0.72 | LMNA (0.45) | ERN1LMNAMAPK1RAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4806637-A | 6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates | SCHERING CORPORATION (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0238285-A2 | 2-Heterocyclylthio penems | SCHERING CORPORATION (US) | 1987-09-23 | — | — | EP | disclosed |