Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 10/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9384934 | 0.80 | LMNA (0.38) | LMNAMAPK1RAB9AERN1CYP3A4 | |
| SCHEMBL5667693 | 0.78 | ERN1 (0.42) | LMNAMAPK1RAB9AERN1CYP3A4 | |
| SCHEMBL8924794 | 0.75 | LMNA (0.42) | LMNAMAPK1RAB9AERN1CYP3A4 | |
| SCHEMBL9191402 | 0.75 | LMNA (0.42) | LMNAMAPK1RAB9AERN1CYP3A4 | |
| SCHEMBL29306874 | 0.74 | ERN1 (0.42) | LMNAMAPK1RAB9AERN1CYP3A4 | |
| SCHEMBL30564477 | 0.74 | LMNA (0.40) | LMNAMAPK1RAB9AERN1CYP3A4 | |
| SCHEMBL9382635 | 0.74 | ERN1 (0.36) | LMNAMAPK1RAB9AERN1CYP3A4 | |
| SCHEMBL7958636 | 0.73 | ERN1 (0.43) | LMNAMAPK1RAB9AERN1CYP3A4 | |
| SCHEMBL9382711 | 0.72 | LMNA (0.39) | LMNAMAPK1RAB9AERN1CYP3A4 | |
| SCHEMBL10548331 | 0.71 | ERN1 (0.40) | LMNAMAPK1RAB9AERN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4806637-A | 6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates | SCHERING CORPORATION (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0238285-A2 | 2-Heterocyclylthio penems | SCHERING CORPORATION (US) | 1987-09-23 | — | — | EP | disclosed |