Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10547517 | 0.94 | SLC6A2 (0.40) | MEN1HTTKMT2ALMNACYP2D6 | |
| SCHEMBL10548825 | 0.93 | KCNH2 (0.42) | MAPTMEN1HTTKMT2ALMNA | |
| SCHEMBL10550485 | 0.90 | LMNA (0.41) | MAPTLMNATP53 | |
| SCHEMBL10798752 | 0.86 | SLC6A9 (0.41) | MAPTHTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10549718 | 0.86 | ALDH1A1 (0.40) | MAPTMEN1HTTKMT2ALMNA | |
| SCHEMBL10548471 | 0.84 | MEN1 (0.39) | MAPTMEN1HTTKMT2ALMNA | |
| SCHEMBL9536524 | 0.84 | MEN1 (0.47) | MAPTMEN1HTTKMT2ALMNA | |
| SCHEMBL10550927 | 0.83 | SLC6A9 (0.46) | MAPTLMNATP53 | |
| SCHEMBL10551752 | 0.80 | SLC6A9 (0.39) | MAPTHTTLMNASMN1; SMN2TP53 | |
| SCHEMBL1151619 | 0.80 | SSTR5 (0.59) | MAPTMEN1HTTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |