Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 1.00 |
| ▸ | CA1 | P00915 | 1/20 | 0.68 |
| ▸ | CA2 | P00918 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | IDE | P14735 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28942175 | 1.00 | TRPV1 (1.00) | TRPV1CA1CA2HSD17B10MAPT | |
| SCHEMBL29530774 | 1.00 | TRPV1 (1.00) | TRPV1CA1CA2HSD17B10MAPT | |
| SCHEMBL159764 | 0.92 | TRPV1 (0.85) | TRPV1CA1CA2HSD17B10MAPT | |
| SCHEMBL155979 | 0.92 | TRPV1 (0.85) | TRPV1CA1CA2HSD17B10MAPT | |
| SCHEMBL155980 | 0.92 | TRPV1 (0.85) | TRPV1CA1CA2HSD17B10MAPT | |
| SCHEMBL30475690 | 0.88 | TRPV1 (0.78) | TRPV1CA1CA2HSD17B10MAPT | |
| SCHEMBL6161575 | 0.87 | TRPV1 (0.78) | TRPV1CA1CA2HSD17B10MAPT | |
| Hydrocaffeoylhexylamide SCHEMBL9346647 | 0.86 | TRPV1 (0.80) | TRPV1HSD17B10MAPTMEN1KMT2A | |
| SCHEMBL9345367 | 0.86 | TRPV1 (0.80) | TRPV1HSD17B10MAPTMEN1KMT2A | |
| SCHEMBL9350021 | 0.86 | TRPV1 (0.80) | TRPV1HSD17B10MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315631-B | Capsaicin derivative, and preparation method and application thereof | 广西医科大学 | 2024-01-05 | — | — | CN | disclosed |
| CN-114315631-A | Capsaicin derivative and preparation method and application thereof | 广西医科大学 | 2022-04-12 | — | — | CN | disclosed |
| US-20190038573-A1 | ION CHANNEL ACTIVATORS AND METHODS OF USE | CLIFF-CARTWRIGHT CORPORATION | 2019-02-07 | — | — | US | disclosed |
| EP-3131541-A1 | ION CHANNEL ACTIVATORS AND METHODS OF USE | Flex Pharma, Inc. (US) | 2017-02-22 | — | — | EP | disclosed |
| US-20170042834-A1 | ION CHANNEL ACTIVATORS AND METHODS OF USE | CLIFF-CARTWRIGHT CORPORATION | 2017-02-16 | — | — | US | disclosed |
| WO-2015160843-A1 | ION CHANNEL ACTIVATORS AND METHODS OF USE | FLEX PHARMA, INC. (US) | 2015-10-22 | — | — | WO | disclosed |
| US-4812446-A | CAPSAICINOID AND SALICYLATE | THE PROCTER & GAMBLE COMPANY (US) | 1989-03-14 | — | — | US | disclosed |
| EP-0306060-A2 | Pharmaceutical products providing enhanced analgesia | THE PROCTER & GAMBLE COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |
| US-4681897-A | CAPSAICIN OR ANALOGUE WITH A NONSTEROIDAL ANALGESIC | THE PROCTER & GAMBLE COMPANY (US) | 1987-07-21 | — | — | US | disclosed |
| US-4599342-A | MIXTURE OF CAPSAICIN WITH OPIOID | THE PROCTER & GAMBLE COMPANY (US) | 1986-07-08 | — | — | US | disclosed |
| EP-0089710-B1 | NOVEL HYDROXYPHENYLACETAMIDES HAVING ANALGESIC AND ANTI-IRRITANT ACTIVITY | THE PROCTER & GAMBLE COMPANY (US) | 1985-07-31 | — | — | EP | disclosed |
| EP-0149544-A2 | Pharmaceutical products providing enhanced analgesia | THE PROCTER & GAMBLE COMPANY (US) | 1985-07-24 | — | — | EP | disclosed |
| US-4424205-A | DEPILLATORIES | THE PROCTER & GAMBLE COMPANY (US) | 1984-01-03 | — | — | US | disclosed |
| EP-0089710-A1 | Novel hydroxyphenylacetamides having analgesic and anti-irritant activity | THE PROCTER & GAMBLE COMPANY (US) | 1983-09-28 | — | — | EP | disclosed |