Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.85 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | GMNN | O75496 | 1/20 | 0.71 |
| ▸ | USP2 | O75604 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | IDE | P14735 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL155979 | 1.00 | TRPV1 (0.85) | TRPV1GPR119MAPTHPGDHSD17B10 | |
| SCHEMBL159764 | 1.00 | TRPV1 (0.85) | TRPV1GPR119MAPTHPGDHSD17B10 | |
| SCHEMBL10548485 | 0.92 | TRPV1 (1.00) | TRPV1GPR119MAPTHPGDHSD17B10 | |
| SCHEMBL29530774 | 0.92 | TRPV1 (1.00) | TRPV1GPR119MAPTHPGDHSD17B10 | |
| SCHEMBL28942175 | 0.92 | TRPV1 (1.00) | TRPV1GPR119MAPTHPGDHSD17B10 | |
| SCHEMBL504255 | 0.87 | TRPV1 (0.70) | TRPV1MAPTHPGDTP53CYP1A2 | |
| SCHEMBL504257 | 0.87 | TRPV1 (0.70) | TRPV1MAPTHPGDTP53CYP1A2 | |
| SCHEMBL9808674 | 0.87 | TRPV1 (0.70) | TRPV1MAPTHPGDTP53CYP1A2 | |
| SCHEMBL29380151 | 0.87 | TRPV1 (0.70) | TRPV1MAPTHPGDTP53CYP1A2 | |
| SCHEMBL10946428 | 0.86 | TRPV1 (0.61) | TRPV1GPR119MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426644-B2 | Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase | MITOTEK, LLC (US) | 2013-04-23 | — | — | US | claimed |
| US-20120059064-A1 | Compositions and Methods For Inhibiting an Isoform of Human Manganese Superoxide Dismutase | MITOTEK, LLC (US) | 2012-03-08 | — | — | US | claimed |
| US-7989499-B2 | Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase | MITOTEK, LLC (US) | 2011-08-02 | — | — | US | claimed |
| US-20080287548-A1 | Compositions and Methods For Inhibiting an Isoform of Human Manganese Superoxide Dismutase | MITOTEK, LLC | 2008-11-20 | — | — | US | claimed |
| EP-1850667-A2 | COMPOSITIONS AND METHODS FOR INHIBITING AN ISOFORM OF HUMAN MANGANESE SUPEROXIDE DISMUTASE | Anziano, Paul Q. (US) | 2007-11-07 | — | — | EP | claimed |
| WO-2006086422-A2 | COMPOSITIONS AND METHODS FOR INHIBITING AN ISOFORM OF HUMAN MANGANESE SUPEROXIDE DISMUTASE | ANZIANO PAUL Q (US) | 2006-08-17 | — | — | WO | claimed |
| US-20130289123-A1 | Compositions and Methods for Inhibiting an Isoform of Human Manganese Superoxide Dismutase | MITOTEK, LLC (US) | 2013-10-31 | — | — | US | disclosed |
| US-8426644-B2 | Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase | MITOTEK, LLC (US) | 2013-04-23 | — | — | US | disclosed |
| US-20120059064-A1 | Compositions and Methods For Inhibiting an Isoform of Human Manganese Superoxide Dismutase | MITOTEK, LLC (US) | 2012-03-08 | — | — | US | disclosed |
| US-7989499-B2 | Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase | MITOTEK, LLC (US) | 2011-08-02 | — | — | US | disclosed |
| US-20080287548-A1 | Compositions and Methods For Inhibiting an Isoform of Human Manganese Superoxide Dismutase | MITOTEK, LLC | 2008-11-20 | — | — | US | disclosed |
| EP-1850667-A2 | COMPOSITIONS AND METHODS FOR INHIBITING AN ISOFORM OF HUMAN MANGANESE SUPEROXIDE DISMUTASE | Anziano, Paul Q. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006086422-A2 | COMPOSITIONS AND METHODS FOR INHIBITING AN ISOFORM OF HUMAN MANGANESE SUPEROXIDE DISMUTASE | ANZIANO PAUL Q (US) | 2006-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289123-A1 | Compositions and Methods for Inhibiting an Isoform of Human Manganese Superoxide Dismutase | SOD1, SOD3, PRDX3 | TRPV1 4807/4885GPR119 4044/4885MAPT 2191/4885 |
| US-20120059064-A1 | Compositions and Methods For Inhibiting an Isoform of Human Manganese Superoxide Dismutase | SOD1, SOD3, PRDX3 | TRPV1 4807/4885GPR119 4044/4885MAPT 2191/4885 |
| US-20080287548-A1 | Compositions and Methods For Inhibiting an Isoform of Human Manganese Superoxide Dismutase | SOD1, SOD3, PRDX3 | TRPV1 4807/4885GPR119 4044/4885MAPT 2191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.