Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.55 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.55 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596569 | 0.86 | KDM4E (0.57) | SMARCA2SMARCA4PBRM1NPC1KDM4E | |
| SCHEMBL3596565 | 0.86 | KDM4E (0.57) | SMARCA2SMARCA4PBRM1NPC1KDM4E | |
| SCHEMBL104152 | 0.84 | KDM4E (0.53) | SMARCA2SMARCA4PBRM1NPC1KDM4E | |
| SCHEMBL103728 | 0.84 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1NPC1KDM4E | |
| SCHEMBL102309 | 0.84 | MEN1 (0.48) | SMARCA2SMARCA4PBRM1KDM4EALDH1A1 | |
| SCHEMBL28593829 | 0.83 | GPR119 (0.49) | SMARCA2SMARCA4PBRM1KDM4EALDH1A1 | |
| SCHEMBL28593831 | 0.83 | GPR119 (0.49) | SMARCA2SMARCA4PBRM1KDM4EALDH1A1 | |
| SCHEMBL103154 | 0.83 | KDM4E (0.67) | SMARCA2SMARCA4PBRM1NPC1KDM4E | |
| SCHEMBL31615949 | 0.83 | KDM4E (0.67) | SMARCA2SMARCA4PBRM1NPC1KDM4E | |
| SCHEMBL28028631 | 0.81 | KDM4E (0.52) | SMARCA2SMARCA4PBRM1NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426113-A1 | CARBINOL COMPOUND HAVING HETEROCYCLIC LINKER | Kowa Company, Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |