Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | CBFB | Q13951 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10547247 | 0.95 | KMT2A (0.45) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL10549493 | 0.89 | MAPT (0.50) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9535357 | 0.89 | KMT2A (0.48) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9535185 | 0.89 | MAPT (0.49) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL10550741 | 0.87 | KMT2A (0.44) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL10550732 | 0.86 | ALDH1A1 (0.45) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL10549281 | 0.86 | SLC6A9 (0.43) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9742527 | 0.86 | MEN1 (0.51) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9535187 | 0.85 | ALDH1A1 (0.45) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL10547215 | 0.85 | POLB (0.49) | POLBSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |