Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | CBFB | Q13951 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536165 | 0.94 | CCR3 (0.56) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL10550247 | 0.89 | MAPT (0.51) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL9536826 | 0.89 | TP53 (0.51) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL9535357 | 0.87 | KMT2A (0.48) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL9535187 | 0.86 | ALDH1A1 (0.45) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL10550741 | 0.85 | KMT2A (0.44) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL9536175 | 0.85 | SLC6A2 (0.48) | MAPTMEN1KMT2AALDH1A1SLC6A2 | |
| SCHEMBL10550732 | 0.85 | ALDH1A1 (0.45) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL9536186 | 0.84 | MAPT (0.56) | MAPTPOLBGAASLC6A2SLC6A4 | |
| SCHEMBL9537470 | 0.84 | KDM4E (0.50) | POLBKDM4EUSP2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |