Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 2/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SI | P14410 | 2/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10368759 | 0.99 | KDM4E (0.43) | PKMKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL20527613 | 0.84 | KDM4E (0.44) | PKMKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL21821192 | 0.77 | KDM4E (0.44) | PKMKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL20527666 | 0.76 | ALDH1A1 (0.41) | PKMKDM4EALDH1A1LMNAMAPT | |
| Bromide SCHEMBL10549297 | 0.75 | PKM (0.41) | PKMKDM4EALDH1A1LMNAMAPT | |
| Bromide SCHEMBL10549322 | 0.75 | PKM (0.41) | PKMKDM4EALDH1A1LMNAMAPT | |
| Bromide SCHEMBL3846585 | 0.74 | KMT2A (0.45) | PKMKDM4EALDH1A1LMNAMAPT | |
| Bromide SCHEMBL10551604 | 0.72 | ALDH1A1 (0.44) | PKMKDM4EALDH1A1LMNAMAPT | |
| Bromide SCHEMBL10550691 | 0.71 | MEN1 (0.47) | PKMKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL10368758 | 0.69 | MEN1 (0.45) | LMNAKMT2ARAB9ACXCR3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831151-A | NEMATOCIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-05-16 | — | — | US | disclosed |