Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10368758 | 0.99 | MEN1 (0.45) | MEN1KMT2APABPC1USP2GSK3B | |
| SCHEMBL20527614 | 0.84 | MEN1 (0.46) | MEN1KMT2APABPC1USP2GSK3B | |
| SCHEMBL21821193 | 0.76 | KMT2A (0.44) | MEN1KMT2APABPC1USP2CYP2C9 | |
| SCHEMBL20527667 | 0.76 | KMT2A (0.39) | MEN1KMT2APABPC1USP2GSK3B | |
| Bromide SCHEMBL10549303 | 0.75 | KMT2A (0.44) | MEN1KMT2APABPC1USP2LMNA | |
| Bromide SCHEMBL3846589 | 0.74 | KMT2A (0.50) | MEN1KMT2APABPC1USP2GSK3B | |
| Hydrochloric Acid SCHEMBL10549618 | 0.73 | CHKA (0.35) | KDM4EMAPTPOLBALDH1A1HPGD | |
| Bromide SCHEMBL10368577 | 0.73 | KMT2A (0.41) | MEN1KMT2AGAAALDH1A1 | |
| Bromide SCHEMBL10551607 | 0.72 | ALDH1A1 (0.44) | MEN1KMT2APABPC1USP2HDAC8 | |
| Bromide SCHEMBL10550683 | 0.71 | PKM (0.44) | KMT2AGSK3BLMNACXCR3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831151-A | NEMATOCIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-05-16 | — | — | US | disclosed |