Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11032841 | 0.83 | PDE3B (0.51) | KMT2AMEN1HTTCYP1A2CYP3A4 | |
| SCHEMBL7436364 | 0.75 | EGLN2 (0.35) | KMT2AMEN1HTTCYP1A2CYP3A4 | |
| SCHEMBL10468427 | 0.71 | PDE3B (0.69) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL10551860 | 0.71 | PDE3B (0.46) | KMT2AGAACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10469492 | 0.70 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10551346 | 0.69 | PDE3B (0.70) | GAACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL10684945 | 0.69 | PDE3B (0.44) | CYP1A2CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL10553489 | 0.69 | PDE3B (0.69) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10554320 | 0.68 | PDE3B (0.46) | KMT2AGAACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8815628 | 0.68 | GAA (0.50) | KMT2AGAACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4783463-A | Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure | RORER PHARMACEUTICAL CORPORATION (US) | 1988-11-08 | — | — | US | claimed |