Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 18/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 18/20 | 0.69 |
| ▸ | PDE4A | P27815 | 2/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.69 |
| ▸ | PDE2A | O00408 | 2/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10469492 | 0.85 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL6052113 | 0.81 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL10657390 | 0.81 | PDE3B (0.98) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10549976 | 0.80 | PDE3B (0.68) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10646114 | 0.76 | PDE3A (0.63) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7395148 | 0.76 | PDE3A (0.63) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10554354 | 0.75 | PDE3A (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL10994729 | 0.74 | PDE3B (0.83) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Ci-930 SCHEMBL10994723 | 0.74 | PDE3B (0.83) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10551547 | 0.73 | PDE3A (0.61) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4847251-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-11 | — | — | US | disclosed |
| EP-0255704-A2 | Pyridazinone derivatives, process for their preparation and their use as medicines | Roche Diagnostics GmbH (DE) | 1988-02-10 | — | — | EP | disclosed |