Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 9/20 | 0.56 |
| ▸ | HTR1A | P08908 | 7/20 | 0.56 |
| ▸ | HTR6 | P50406 | 6/20 | 0.54 |
| ▸ | HTR2A | P28223 | 6/20 | 0.53 |
| ▸ | HTR1B | P28222 | 5/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2538876 | 0.86 | SPR (0.61) | HTR1DHTR1AHTR6HTR2AHTR1B | |
| SCHEMBL10551426 | 0.81 | CSNK2A1 (0.51) | HTR1DHTR1AHTR6HTR2AHTR1B | |
| SCHEMBL10743461 | 0.81 | HTR1A (0.59) | HTR1DHTR1AHTR6HTR2AHTR1B | |
| SCHEMBL1578266 | 0.78 | HTR1D (0.57) | HTR1DHTR1AHTR6HTR2AHTR1B | |
| SCHEMBL10577690 | 0.78 | HTR1D (0.61) | HTR1DHTR1AHTR6HTR2AHTR1B | |
| SCHEMBL9598772 | 0.76 | HTR1D (0.63) | HTR1DHTR1AHTR6HTR2AHTR1B | |
| SCHEMBL10552982 | 0.75 | HTR1D (0.69) | HTR1DHTR1AHTR6HTR2AHTR1B | |
| SCHEMBL9800420 | 0.75 | HTR1D (0.61) | HTR1DHTR1AHTR6HTR2AHTR1B | |
| SCHEMBL273110 | 0.75 | HTR1D (0.56) | HTR1DHTR1AHTR6HTR2AHTR1B | |
| SCHEMBL13333259 | 0.75 | HTR6 (0.76) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4839377-A | TREATMENT OF MIGRAINE | GLAXO GROUP LIMITED (GB) | 1989-06-13 | — | — | US | disclosed |