Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.48 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834995 | 0.86 | PDE4A (0.55) | RAB9ANPC1MEN1KMT2APKM | |
| SCHEMBL10557685 | 0.83 | KDM4E (0.49) | MEN1KMT2AMAPTGSK3B | |
| SCHEMBL9379065 | 0.81 | RAB9A (0.55) | RAB9ANPC1MEN1KMT2APKM | |
| SCHEMBL9834410 | 0.81 | PDE4A (0.46) | RAB9ANPC1MEN1KMT2APKM | |
| SCHEMBL9834452 | 0.80 | AURKA (0.49) | SMN1; SMN2LMNAIRAK4TUBB4ATUBB | |
| SCHEMBL9835322 | 0.77 | PDE4A (0.45) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10478082 | 0.76 | KMT2A (0.59) | RAB9ANPC1MEN1KMT2APKM | |
| SCHEMBL9375666 | 0.76 | NPC1 (0.59) | RAB9ANPC1MEN1KMT2APKM | |
| SCHEMBL9833536 | 0.75 | NPC1 (0.45) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16766582 | 0.75 | CSNK1E (0.80) | RAB9ANPC1MEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863945-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0271040-A2 | Pyrrolobenzimidazoles, process for their preparation, and medicaments | Roche Diagnostics GmbH (DE) | 1988-06-15 | — | — | EP | disclosed |