Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 15/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9196436 | 0.91 | P2RX3 (0.44) | P2RX3TP53THRBLMNAKDM4E | |
| SCHEMBL10559203 | 0.90 | P2RX3 (0.49) | P2RX3 | |
| SCHEMBL10557407 | 0.82 | MEN1 (0.47) | P2RX3TP53THRBLMNAKDM4E | |
| SCHEMBL9196438 | 0.82 | P2RX3 (0.44) | P2RX3TP53THRBLMNAKDM4E | |
| SCHEMBL9196048 | 0.81 | P2RX3 (0.43) | P2RX3HPGDADORA3 | |
| SCHEMBL9202874 | 0.80 | P2RX3 (0.48) | P2RX3 | |
| SCHEMBL10559101 | 0.79 | P2RX3 (0.47) | P2RX3TP53THRBLMNAKDM4E | |
| SCHEMBL9202879 | 0.74 | ALDH1A1 (0.38) | P2RX3KDM4EMAPT | |
| SCHEMBL9196053 | 0.72 | ALDH1A1 (0.44) | P2RX3HPGD | |
| SCHEMBL10559207 | 0.72 | P2RX3 (0.49) | P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824848-A | TREATMENT, PREVENTION OF NERVOUS SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0237289-A2 | Pyrazolo [3,4-d] pyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-09-16 | — | — | EP | disclosed |